Hai guys, aku mau berbagi sedikit nih tentang
pengalamanku mengikuti Workshop on Nanotechnology for Enviromental and Medical
Aplications by Prof. Dr. Santiago Gomez Ruiz yang baru saja diadakan di
Aula Gedung B Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sebelas Maret Surakarta, Jumat 25 Januari
2013 pukul 09.00 WIB - selesai.
Acara ini diadakan fakultas dalam rangka
penyambutan Dies Natalies, dan yang diberi tanggung jawab untuk menjalankannya
jurusan kimia, jurusanku. Ya, walau aku tidak banyak membantu dalam keberlangsungan
acara, setidaknya aku turut menbantu di bagian konsumsi. Oia, acara ini
terbuka untuk umum, sayangnya pada acara kali ini jumlah peserta yang datang terbilang
sedikit, mungkin dikarenakan liburan. Ya, memang susah untuk
mengumpulkan massa pada saat liburan seperti ini.
Oia,
di sini aku akan sedikit membagi materi yang dibawakan Prof. Dr. Santiago Gómez-Ruiz (Professor of Inorganic Chemistry at the Departamento de
Quimica Inorganica y Analitica, Universidad Rey Juan Carlos, Calle Tulipan s/n,
28933, Mostoles (Madris), Spain), tapi abstarknya saja. Jujur saat Prof.
Santiago menyampaikan materinya aku juga tidak mengerti sama sekali, oopss maksudnya belum mengerti. Selain karena my
english is bad, aku juga belum paham tentang materi yang dibawakan. Maklumlah
aku mahasiswa semester 3, belum mendapatkan materi seperti itu. Walaupun
tidak mengerti aku mencoba untuk mendengarkan saja, mungkin saja ada kata-kata
yang akan ku ingat. :)
Waktu
Prof. Santiago menyampaikan materinya aku tidak mengambil gambar karena terlalu
sibuk mengurus konsumsi. Pikirku juga sudah ada Tim Pubdekdok, jadi aku bisa
meminta fotonya. Tapi karna sampai sekarang aku belum dapat fotonya, aku
mencoba mencari di internet dan akhirnya. Ini dia Prof. Santiago. . . :)
Mungkin
basa-basinya sampai di sini saja, kita langsung menginjak ke materi yang dibawakannya.
Check
this Out.
Materi
I
TITANIUM
OXIDE-BASED MATERIALS AS PHOTOCATALYSTS FOR THE DECONTAMINATION OF WATER
Since
the discovery of hydrogen evolution through the photoelectrochemical splitting
of water on n-type TiO2 electrodes, the productio of hydrogen using solar energy has
been considered one og the most important approaches to solve the worldwide
extended energy problem. In addition, using similar approaches, analogous
systems based also in TiO2
are useful
photocatalysts for the elimination of organic pollutants of waters.
These applications have attracted in interest of many scientists which are
currently working on the increase of the effectivity of these systems by
extending the response of wide-bandgap semiconductor photocatalysts into the
visible light range, which seems to be critical for the exponential advance of
photocatalysts in enviromental remediation and renewable energy generation.
The strategy of cation and/or anion doping has been
widely used in titanium oxide syntheses to modify the electronic structure and,
thus, response ranges of photocatalysts.
Following different reported synthetic methods, we have
recently doped mesoporous nano-sized titanium oxide with zinc ions using
different synthetic and calcination methods, in order to observe the influence
of the metal ion in the band gap value, as well as on the structural and
catalytic properties of TiO2-based materials.
Our latest result show the formation of nanoparticles of
mesoporous titanium oxide that on raising the zinc amount show a detriment of
the band gap which may be useful for the use of visible light for the
decontamination of waters. In addition, the crystallinity and others structural
parameters have also been strongly modified upon the doping with zinc.
This communication will include the most recent result in
this field with a detailed study of the photocatalytic reactions for the
generation of polluted waters.
___________________________________________________________
1See for example: X. Chen, S. Shen, L. Guo, S. S. Mao
Chem. Rev. 2010, 110, 6503.
2See for example: a) S. S. Mao, X. Chen, Int. J.Energy
Res. 2007, 31, 619; b) H. Tada, T. Kiyonaga, S. Naya, Chem. Soc. Rev., 2009,
38, 1849.
3see for example: R. Asahi, T. Kiyonaga, S. Naya, Chem.
Soc. Rev. 2009, 38, 1849.
4See for example: R. Asahi, T. Morikawa, T. Ohwaki, K.
Aoki, Y. Taga, Science 2001, 293, 269.
5S. Sánchez-Munoz, D. Pérez-Quintanilla, S.
Gómez-Ruiz, Mat. Res. Bull. 2013, 48, 250.
Materi II
NEW DIRECTIONS IN THE FIGHT AGAINST IN CANCER. IN SEARCH
OF NOVEL NANOSYSTEMS FOR THE TREATMENT OF BONE TUMORS.
Nanostructured silica-based materials such as
MCM-41, SBA-15, and some other have been studied in a wide variety of
biological applications. These materials have been loaded with many drugs such
as anti-inflammatory/analgesic drugs, antibiotics, bactericidal,
anti-hypertensive drugs, antidepressant, anti-ulcer and anti-osteoporotic
drugs, being able to locally deliver drugs for the treatment of bone phatologies
and complex diseases. The first study of the functionalization of these
materials with metal complexes with anticancer activity was carried out with
cisplatin, and similar approach was recently reported by our group, who has
synthesized titanocene-functionalized MCM-41 or SBA-15 starting from different
titanocene dichloride derivatives with anticancer activity.
Thus, our group started with the functionalization of
nanostructured silica with many other metals complexes with cytotoxic
properties and in these investigations even metal nanoparticles have been
supported onto the silica-based nanostructured scaffolds and have been tested
against several cancer cell lines observing interesting result.
For our studies, one can see that the higher permeation
of the membranes of the cancer cells, in comparison to the healthy cells, in
one of the advantages for the specific use of these materials in chemotherapy.
In addition, these materials seem to be useful as bone fillers for in situ
treatment of bone tumors such as osteosarcoma or condroblasma upon local
implantations which may avoid recurrence of the tumor.
The deep study of these novel nanosystems led us to think
the possibility too prepare similar materials fuctionalized with natural
products with potential application as anticancer drugs and less number of side
effect, due to their convenient antineoplasic properties.
In this communication an overview of the recently
published result, as well as the ongoing investigations of our group in this
field will be presented and discussed.
___________________________________________________________________
1See for example: M. Vallet-Regĺ, M. Colilla, B. González,
Chem. Soc. Rev. 2011, 40, 596-607.
2C. Y. Lai, B. G. Trewyn, D. M. Jeftinija, K. Jeftinija, S.
Xu, S. Jeftinija, V. S. Lin, J. Am. Chem. Soc. 2003, 125, 4451-4459.
3See for the examples: a) D. Pérez-Quintanilla, S.
Gómez-Ruiz, G. N. Kaluderović, Ž. Žižak, Z. D. Juranić, I. Sierra, S. Prashar,
I. Del Hierro, M. Fajardo, Chem. Eur. J., 2009, 15, 5588-5597; b) G. N.
Kaluderović, D. Pérez-Quintanilla, I. Sierra, S. Prashar, I. Del Hierro, Ž.
Žižak, Z. D. Juranić, M. Fajardo, S. Gómez-Ruiz, J. Mat. Chem. 2010, 20,
806-814; c) G. N. Kaluderović, D. Pérez-Quintanilla, Ž. Žižak, Z. D. Juranić,
S. Gómez-Ruiz, Dalton Trans. 2010, 39, 2597-2608; d) A. García-Penas, S.
Gómez-Ruiz, D. Pérez-Quintanilla, R. Paschke, I. Sierra, S. Prashar, I. Del
Hierro, G. N. Kaluderović, J. Inorg. Biochem. 2012, 106, 100-110.
4S. Sánchez-Munoz, S. Gómez-Ruiz, D. Pérez-Quintanilla, S.
Morante-Zarcero, I. Sierra, S. Prashar, R. Paschke, G. N. Kaluderović,
ChemMedChem 2012, 7, 670-679.
Sumber Prof. Dr. Santiago Gómez-Ruiz
Picture
from http://www.escet.urjc.es/~sgomez/
