Workshop on Nanotechnology for Enviromental and Medical Aplications

         Hai guys, aku mau berbagi sedikit nih tentang pengalamanku mengikuti Workshop on Nanotechnology for Enviromental and Medical Aplications by Prof. Dr. Santiago Gomez Ruiz yang baru saja diadakan di Aula Gedung B Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Sebelas Maret Surakarta, Jumat 25 Januari 2013 pukul 09.00 WIB - selesai.
         Acara ini diadakan fakultas dalam rangka penyambutan Dies Natalies, dan yang diberi tanggung jawab untuk menjalankannya jurusan kimia, jurusanku. Ya, walau aku tidak banyak membantu dalam keberlangsungan acara, setidaknya aku turut menbantu di bagian konsumsi. Oia, acara ini terbuka untuk umum, sayangnya pada acara kali ini jumlah peserta yang datang terbilang sedikit, mungkin dikarenakan liburan. Ya, memang susah untuk mengumpulkan massa pada saat liburan seperti ini.

  Oia, di sini aku akan sedikit membagi materi yang dibawakan Prof. Dr. Santiago Gómez-Ruiz (Professor of Inorganic Chemistry at the Departamento de Quimica Inorganica y Analitica, Universidad Rey Juan Carlos, Calle Tulipan s/n, 28933, Mostoles (Madris), Spain), tapi abstarknya saja. Jujur saat Prof. Santiago menyampaikan materinya aku juga tidak mengerti sama sekali, oopss maksudnya belum mengerti. Selain karena my english is bad, aku juga belum paham tentang materi yang dibawakan. Maklumlah aku mahasiswa semester 3, belum mendapatkan materi seperti itu. Walaupun tidak mengerti aku mencoba untuk mendengarkan saja, mungkin saja ada kata-kata yang akan ku ingat. :)

Waktu Prof. Santiago menyampaikan materinya aku tidak mengambil gambar karena terlalu sibuk mengurus konsumsi. Pikirku juga sudah ada Tim Pubdekdok, jadi aku bisa meminta fotonya. Tapi karna sampai sekarang aku belum dapat fotonya, aku mencoba mencari di internet dan akhirnya. Ini dia Prof. Santiago. . . :)

Mungkin basa-basinya sampai di sini saja, kita langsung menginjak ke materi yang dibawakannya. 

Check this Out.

Materi I

TITANIUM OXIDE-BASED MATERIALS AS PHOTOCATALYSTS FOR THE DECONTAMINATION OF WATER

Since the discovery of hydrogen evolution through the photoelectrochemical splitting of water on n-type TiO₂ electrodes, the productio of hydrogen using solar energy has been considered one og the most important approaches to solve the worldwide extended energy problem. In addition, using similar approaches, analogous systems based also in  TiO₂ are useful photocatalysts for the elimination of organic pollutants of waters.
These applications have attracted in interest of many scientists which are currently working on the increase of the effectivity of these systems by extending the response of wide-bandgap semiconductor photocatalysts into the visible light range, which seems to be critical for the exponential advance of photocatalysts in enviromental remediation and renewable energy generation.

The strategy of cation and/or anion doping has been widely used in titanium oxide syntheses to modify the electronic structure and, thus, response ranges of photocatalysts. 

Following different reported synthetic methods, we have recently doped mesoporous nano-sized titanium oxide with zinc ions using different synthetic and calcination methods, in order to observe the influence of the metal ion in the band gap value, as well as on the structural and catalytic properties of TiO2-based materials. 

Our latest result show the formation of nanoparticles of mesoporous titanium oxide that on raising the zinc amount show a detriment of the band gap which may be useful for the use of visible light for the decontamination of waters. In addition, the crystallinity and others structural parameters have also been strongly modified upon the doping with zinc. 

This communication will include the most recent result in this field with a detailed study of the photocatalytic   reactions for the generation of polluted waters.

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¹See for example: X. Chen, S. Shen, L. Guo, S. S. Mao Chem. Rev. 2010, 110, 6503.

²See for example: a) S. S. Mao, X. Chen, Int. J.Energy Res. 2007, 31, 619; b) H. Tada, T. Kiyonaga, S. Naya, Chem. Soc. Rev., 2009, 38, 1849.

³see for example: R. Asahi, T. Kiyonaga, S. Naya, Chem. Soc. Rev. 2009, 38, 1849.

⁴See for example: R. Asahi, T. Morikawa, T. Ohwaki, K. Aoki, Y. Taga, Science 2001, 293, 269.

⁵S. Sánchez-Munoz, D. Pérez-Quintanilla, S. Gómez-Ruiz, Mat. Res. Bull. 2013, 48, 250.  

Materi II 

NEW DIRECTIONS IN THE FIGHT AGAINST IN CANCER. IN SEARCH OF NOVEL NANOSYSTEMS FOR THE TREATMENT OF BONE TUMORS.

Nanostructured silica-based materials such as MCM-41, SBA-15, and some other have been studied in a wide variety of biological applications. These materials have been loaded with many drugs such as anti-inflammatory/analgesic drugs, antibiotics, bactericidal, anti-hypertensive drugs, antidepressant, anti-ulcer and anti-osteoporotic drugs, being able to locally deliver drugs for the treatment of bone phatologies and complex diseases. The first study of the functionalization of these materials with metal complexes with anticancer activity was carried out with cisplatin, and similar approach was recently reported by our group, who has synthesized titanocene-functionalized MCM-41 or SBA-15 starting from different titanocene dichloride derivatives with anticancer activity. 

Thus, our group started with the functionalization of nanostructured silica with many other metals complexes with cytotoxic properties and in these investigations even metal nanoparticles have been supported onto the silica-based nanostructured scaffolds and have been tested against several cancer cell lines observing interesting result.

For our studies, one can see that the higher permeation of the membranes of the cancer cells, in comparison to the healthy cells, in one of the advantages for the specific use of these materials in chemotherapy. In addition, these materials seem to be useful as bone fillers for in situ treatment of bone tumors such as osteosarcoma or condroblasma upon local implantations which may avoid recurrence of the tumor. 

The deep study of these novel nanosystems led us to think the possibility too prepare similar materials fuctionalized with natural products with potential application as anticancer drugs and less number of side effect, due to their convenient antineoplasic properties.

In this communication an overview of the recently published result, as well as the ongoing investigations of our group in this field will be presented and discussed.

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¹See for example: M. Vallet-Regĺ, M. Colilla, B. González, Chem. Soc. Rev. 2011, 40, 596-607.

²C. Y. Lai, B. G. Trewyn, D. M. Jeftinija, K. Jeftinija, S. Xu, S. Jeftinija, V. S. Lin, J. Am. Chem. Soc. 2003, 125, 4451-4459.

³See for the examples: a) D. Pérez-Quintanilla, S. Gómez-Ruiz, G. N. Kaluderović, Ž. Žižak, Z. D. Juranić, I. Sierra, S. Prashar, I. Del Hierro, M. Fajardo, Chem. Eur. J., 2009, 15, 5588-5597; b) G. N. Kaluderović, D. Pérez-Quintanilla, I. Sierra, S. Prashar, I. Del Hierro, Ž. Žižak, Z. D. Juranić, M. Fajardo, S. Gómez-Ruiz, J. Mat. Chem. 2010, 20, 806-814; c) G. N. Kaluderović, D. Pérez-Quintanilla, Ž. Žižak, Z. D. Juranić, S. Gómez-Ruiz, Dalton Trans. 2010, 39, 2597-2608; d) A. García-Penas, S. Gómez-Ruiz, D. Pérez-Quintanilla, R. Paschke, I. Sierra, S. Prashar, I. Del Hierro, G. N. Kaluderović, J. Inorg. Biochem. 2012, 106, 100-110.

⁴S. Sánchez-Munoz, S. Gómez-Ruiz, D. Pérez-Quintanilla, S. Morante-Zarcero, I. Sierra, S. Prashar, R. Paschke, G. N. Kaluderović, ChemMedChem 2012, 7, 670-679.  

Sumber  Prof. Dr. Santiago Gómez-Ruiz

Picture from http://www.escet.urjc.es/~sgomez/